[ CAS NO. 171599-83-0 ] Sildenafil Citrate 99.83%
Sildenafil is an inhibitor of phosphodiesterase type-5 (PDE-5). It is used in the treatment of erectile dysfunction. Sildenafil inhibits the enzyme phosphodiesterase type-5, which prevents the conversion of cyclic guanosine monophosphate to cyclic adenosine monophosphate, and this results in relaxation of smooth muscle cells and increased blood flow to the corpus cavernosum. The PDE-5 inhibitors are selective for human PDE-5 and do not inhibit PDEs 1, 2, 3, or 6. The inhibition of PDE-5 by sildenafil is reversible. Sildenafil has been shown to be a potent inhibitor of cyclase activity in vitro. br> The LC/MS/MS method was developed to measure the concentration of sildenafil in human serum. This analytical method provides a linear calibration curve with limits of quant
[ CAS NO. 171599-83-0 ] Sildenafil citrate – Bio-X ™
Sildenafil is an inhibitor of phosphodiesterase type-5 (PDE-5). It is used in the treatment of erectile dysfunction. Sildenafil inhibits the enzyme phosphodiesterase type-5, which prevents the conversion of cyclic guanosine monophosphate to cyclic adenosine monophosphate, and this results in relaxation of smooth muscle cells and increased blood flow to the corpus cavernosum. The PDE-5 inhibitors are selective for human PDE-5 and do not inhibit PDEs 1, 2, 3, or 6. The inhibition of PDE-5 by sildenafil is reversible. Sildenafil has been shown to be a potent inhibitor of cyclase activity in vitro. br> The LC/MS/MS method was developed to measure the concentration of sildenafil in human serum. This analytical method provides a linear calibration curve with limits of quant
[CAS NO. 103-81-1] 2-Phenylacetamide, >99% (GC)
2-Phenylacetamide is a nitro, acetate extract that has been shown to have antimicrobial activity. It can inhibit HIV infection and has been investigated as an antiviral drug. 2-Phenylacetamide binds to the 2-adrenergic receptor, which is found in high concentrations in the brain and inhibits the release of neurotransmitters. It also binds to κ-opioid receptors and sodium carbonate, which are found on cells throughout the body. The biological properties of this substance have not been fully elucidated but some studies suggest that it may be able to inhibit microbial metabolism or stimulate monoamine neurotransmitters.
[CAS NO. 131707-23-8] Arbidol hydrochloride,99% by HPLC
Umifenovir (131707-23-8) is a broad-spectrum antiviral medication.1 It has shown activity against influenza A,B,and C, respiratory syncytial, SARS-CoV, adeno, parainfluenza type 5, polio, rhino, coxsackie, hanta, chikungungya, hepatitis B and C viruses.2,3 It blocks hemagglutinin-mediated membrane fusion of influenza virus particles.2 Umifenovir has recently been shown to inhibit SARS-CoV2 infection by blocking virus entry as well as release from endolysosomes during intracellular trafficking.5 It has been suggested that Umifenovir may block trimerization of the spike glycoprotein, a key step in host cell adhesion.6
[CAS NO. 131707-25-0] Umifenovir
[CAS NO. 136-47-0] Tetracaine hydrochloride (HCl)
[CAS NO. 171599-83-2] Sildenafil, 98% by HPLC
Sildenafil is an inhibitor of phosphodiesterase type-5 (PDE-5). It is used in the treatment of erectile dysfunction. Sildenafil inhibits the enzyme phosphodiesterase type-5, which prevents the conversion of cyclic guanosine monophosphate to cyclic adenosine monophosphate, and this results in relaxation of smooth muscle cells and increased blood flow to the corpus cavernosum. The PDE-5 inhibitors are selective for human PDE-5 and do not inhibit PDEs 1, 2, 3, or 6. The inhibition of PDE-5 by sildenafil is reversible. Sildenafil has been shown to be a potent inhibitor of cyclase activity in vitro. br> The LC/MS/MS method was developed to measure the concentration of sildenafil in human serum. This analytical method provides a linear calibration curve with limits of quant
[CAS NO. 94-24-6, 136-47-0] Tetracaine, 99% (GC), powder
Tetracaine also known as amethocaine (trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. It can be applied as a cream or as a patcvh, plaster or peel. In regard to its mode of action, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
[CAS NO. 94-24-6] Tetracaine
[CAS NO.100-07-2 ] 4-Methoxybenzoylchloride
p-Anisoyl chloride is a compound that has been shown to inhibit the growth of cancer cells in vitro. It also has significant cytotoxicity, which may be due to its ability to cause the hydrolysis of serine protease. p-Anisoyl chloride is synthesized by reacting acetic anhydride with hydrochloric acid and sodium hydroxide solution in a nonpolar solvent. This reaction leads to the formation of bis(p-anisoyl)chloride, which can then react with pyrimidine compounds. The reaction mechanism for this synthesis is Friedel-Crafts acylation reaction.
